International Journal of Analytical Chemistry
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Acceptance rate40%
Submission to final decision55 days
Acceptance to publication21 days
CiteScore3.000
Journal Citation Indicator0.360
Impact Factor1.698

Ascorbic Acid Content and Antioxidant Activities of White and Brown Teff [Eragrostic tef (Zucc.)Trotter] Grains and Injera

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International Journal of Analytical Chemistry publishes research reporting new experimental results and chemical methods, especially in relation to important analytes, difficult matrices, and topical samples.

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Chief Editor, Professor Charles L. Wilkins, is a Distinguished Professor of Chemistry and Biochemistry at the University of Arkansas, USA. His research focuses on the development of novel analytical chemistry instrumentation and analysis paradigms.

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Research Article

Evaluation of Antibacterial and Anticancer Characteristics of Silver Nanoparticles Synthesized from Plant Extracts of Wrightia tinctoria and Acacia chundra

The study showed the ability to synthesize environmentally friendly silver nanoparticles (AgNPs) using extracts from Wrightia tinctoria seeds and Acacia chundra stems. Surface plasmon resonance peaks in the UV-Vis absorption spectra of both plant extracts verified AgNP synthesis. The structural and morphological properties of the AgNPs were investigated using analytical techniques such as XRD, FTIR, TEM, and EDAX. The AgNPs have an FCC crystalline structure, according to XRD study, and their sizes range from 20 to 40 nm, according to TEM images. Based on the results, these plant extracts have been identified as suitable bioresources for AgNP production. The study also showed that both AgNPs had significant levels of antibacterial activity when tested on four different microbial strains using the agar-well diffusion method. The bacteria tested included two Gram-positive strains (Staphylococcus aureus and Micrococcus luteus) and two Gram-negative strains (Proteus vulgaris and Escherichia coli). Furthermore, the AgNPs were found to have a significant anticancer effect on MCF-7 cell lines, suggesting that they may be useful in therapeutic applications. Overall, this research highlights the potential of the plant extracts considered as a source for synthesizing eco-friendly AgNPs with potential applications in medicine and other fields.

Research Article

Neonicotinoid Analysis in Sunflower (Helianthus annuus) Honey Samples Collected around Tekirdag in Turkey

In recent years, the widespread use of neonicotinoids in agricultural areas has caused environmental pollution due to its lower toxicity to mammals. Honey bees, which are considered as biological indicators of environmental pollution, can carry these pollutants to the hives. Forager bees returning from sunflower crops that have been treated with neonicotinoids treated sunflower fields cause residue accumulation in the hives, which reason colony-level adverse effects. This study analyses neonicotinoid residues in sunflower (Helianthus annuus) honey sampled by beekeepers from Tekirdag province. Honey samples have been subjected to liquid-liquid extraction methods before liquid chromatography-mass spectrometry (LC-MS/MS). The method validation was carried out to fulfill all the necessary requirements of procedures SANCO/12571/2013. Accuracy was in the range of 93.63–108.56%, for recovery in the range of 63.04–103.19%, and for precision in the range 6.03–12.77%. Detection and quantification limits were determined according to the maximum residue limits of each analyte. No neonicotinoid residues were found above the maximum residue limit in the sunflower honey samples analysed.

Research Article

Correlation between SMADs and Colorectal Cancer Expression, Prognosis, and Immune Infiltrates

Background. In recent years, the incidence and mortality of colorectal cancer (CRC) are increasing, and the 5-year survival rate of advanced metastatic CRC is poor. Small mothers against decapentaplegic (SMAD) superfamily are intracellular signal transduction proteins associated with the development and prognosis of a variety of tumors. At present, no study has systematically analysed the relationship between SMADs and CRC. Methods. Here, R3.6.3 was used to analyse the expression of SMADs in pan-cancer and CRC. Protein expression of SMADs were analysed by Human Protein Atlas (HPA). Gene expression profiling interactive analysis (GEPIA) was used to evaluate the correlation between SMADs and tumor stage in CRC. The effect of R language and GEPIA on prognosis was analysed. Mutation rates of SMADs in CRC were determined by cBioPortal, and potentially related genes were predicted using GeneMANIA. R analysis was used to correlate immune cell infiltration in CRC. Results. Both SMAD1 and SMAD2 were found to be weakly expressed in CRC and correlated with the immune invasion level. SMAD1 was correlated with patient prognosis, and SMAD2 was correlated with tumor stage. SMAD3, SMAD4, and SMAD7 were all expressed at low levels in CRC and associated with a variety of immune cells. SMAD3 and SMAD4 proteins were also expressed at low levels, and SMAD4 had the highest mutation rate. SMAD5 and SMAD6 were overexpressed in CRC, and SMAD6 was also associated with patient overall survival (OS) and CD8+ T cells, macrophages, and neutrophils. Conclusions. Our results reveal innovative and strong evidence that SMADs can be used as biomarkers for the treatment and prognosis of CRC.

Research Article

Change in Serum Uric Acid is a Useful Predictor of All-Cause Mortality among Community-Dwelling Persons

There is limited research on the association between longitudinal variability in serum uric acid (SUA) and all-cause mortality in the general population, although recent studies have suggested that changes in SUA are associated with all-cause mortality in adults. This study aims to examine the association between percentage change in SUA (%dSUA = 100 × (cohort 2 SUA − cohort 1 SUA)/(time × cohort 1 SUA) and all-cause mortality. This study is based on 1,301 participants, of whom 543 were male (63 ± 11 years) and 758 were female (63 ± 9 years). We obtained adjusted relative risk estimates for all-cause mortality and used a Cox proportional hazards model, adjusted for possible confounders, to determine the hazard ratio (HR) and 95% confidence interval (CI) of %dSUA. Of all the participants, 79 (6.1%) were deceased, and of these, 45 were male (8.3%) and 34 were female (4.5%). The multivariable-adjusted HRs (95% CI) for all-cause mortality for the first, second to fourth (reference), and fifth %dSUA quintiles were 3.79 (1.67–8.48), 1.00, and 0.87 (0.29–2.61) for male participants and 4.00 (1.43–11.2), 1.00, and 1.19 (0.46–3.05) for female participants, respectively. Participants with a body mass index of <22 kg/m2 had a significantly higher HR, forming a U-shaped curve for the first (HR, 7.59; 95% CI, 2.13–27.0) and fifth quintiles (HR, 2.93; 95% CI, 1.05–8.18) relative to the reference. Percentage change in SUA is independently and significantly associated with future all-cause mortality among community-dwelling persons.

Research Article

A Novel, Simple, and Reliable Spectrophotometric Determination of Total Hexavalent Chromium by Complexation with a New Reagent of Thiazole Linked to 2H-Chromen-2-One

Hexavalent chromium is a known environmental contaminant and carcinogen. In the current work, a simple, rapid, and reliable direct spectrophotometric method was used for the determination of total Cr (VI) in environmental samples. Acid-base equilibria and ionization constant (pKa) of the new reagent 3-(2-(2-(4-(trifluoromethyl)benzylidene)hydrazineyl) thiazol-4-yl)-2H-chromen-2-one (thiazole linked to 2H-chromen-2-one, TFZ) were investigated. The value of pKa for the reagent was found to be 7.6 which was initially reported. The reaction of the TFZ ligand with Cr (VI) was optimized to produce a highly absorbent complex at 370 nm and pH 7.0 within 1 min. With a correlation coefficient of 0.9994, the linear concentration range ranges from 2 to 20,000 ng·mL−1. The detection limit and quantification limit were 0.73 and 2.43 ng·mL−1, respectively. The method has high precision with relative standard deviations less than 1.0 and high accuracy with recovery of 100 ± 2%. A large excess of cations and anions did not interfere with the determination of Cr (VI). The proposed method was successfully applied to the determination of Cr (VI) in cement samples. The current method could be useful for the routine analysis of Cr (VI) in environmental labs.

Research Article

Comparative Pharmacokinetic Study of 5 Active Ingredients after Oral Administration of Zuogui Pill in Osteoporotic Rats with Different Syndrome Types

Zuogui Pill is a kidney-yin-tonifying formula in traditional Chinese medicine that is widely used to manage osteoporosis with kidney-yin-deficiency in China. Herein, an efficient and accurate high-performance liquid chromatography-tandem mass spectrometry method was developed to determine the concentrations of 5 bioactive compounds in rat plasma following oral administration of Zuogui Pill. Because drug absorption and distribution differ under physiological and pathological conditions, the established method was used to quantify blood components and dynamic change in osteoporotic rats with different syndrome types. Moreover, integrated pharmacokinetic study was conducted to describe the overall pharmacokinetic characteristics of traditional Chinese medicine. The results showed that the absorption, distribution, and metabolism of Zuogui Pill varied widely under different states. The bioavailability of most active components showed significant advantages in osteoporotic rats with kidney-yin-deficiency, which corresponds to the opinion that Zuogui Pill has the effect of nourishing kidney-yin. It is hoped that this finding could interpret the pharmacodynamic substances and mechanism of Zuogui Pill in the treatment of osteoporosis with kidney-yin-deficiency.

International Journal of Analytical Chemistry
 Journal metrics
See full report
Acceptance rate40%
Submission to final decision55 days
Acceptance to publication21 days
CiteScore3.000
Journal Citation Indicator0.360
Impact Factor1.698
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